2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Related Products

PDF 2.47 MB

Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.

Nucleoside Antimetabolite/Analog Related Products (1834):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W013159S
    2'-Deoxyguanosine 5'-monophosphate-13C10,15N5 disodium
    		98.97%
    2'-Deoxyguanosine 5'-monophosphate-13C10,15N5 (dGMP-13C10,15N5) disodium is the 13C and 15N labeled 2'-Deoxyguanosine 5'-monophosphate disodium (HY-W013159). 2'-Deoxyguanosine 5'-monophosphate (5′-dGMP) disodium is a mononucleotide having guanine as the nucleobase. 2'-Deoxyguanosine 5'-monophosphate disodium is a reactant involved in analysis of self-assembling in solution and nucleation/growth of G-qudruplexes, nucleophilic trapping and reductive alkylation. 2'-Deoxyguanosine 5'-monophosphate disodium can be used as an oxidizable target. 2'-Deoxyguanosine 5'-monophosphate disodium is a nucleic acid guanosine triphosphate (GTP) derivative and is a nucleotide precursor used in DNA synthesis.
    2'-Deoxyguanosine 5'-monophosphate-<sup>13</sup>C<sub>10</sub>,<sup>15</sup>N<sub>5</sub> disodium
  • HY-B0003A
    1'-epi Gemcitabine hydrochloride
    1'-epi Gemcitabine hydrochloride is the isomer of Gemcitabine hydrochloride (HY-B0003), and can be used as an experimental control. Gemcitabine Hydrochloride (LY 188011 Hydrochloride) is a pyrimidine nucleoside analog antimetabolite and an antineoplastic agent. Gemcitabine Hydrochloride inhibits DNA synthesis and repair, resulting in autophagyand apoptosis.
    1'-epi Gemcitabine hydrochloride
  • HY-154496
    2’-Deoxy-N3-methylcytidine
    2’-Deoxy-N3-methylcytidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2’-Deoxy-N3-methylcytidine
  • HY-146247A
    4'-Fluorouridine triphosphate sodium
    4'-Fluorouridine triphosphate (4'-Fluorouridine TP) sodium is a bioactive 5’-triphosphate form of 4'-Fluorouridine (EIDD-2749) (HY-146246). 4'-Fluorouridine triphosphate can effectively bind to RSV RdRP.
    4'-Fluorouridine triphosphate sodium
  • HY-101969
    Pseudothymidine
    		Chemical 99.44%
    Pseudothymidine is a C-nucleoside analog of thymidine.
    Pseudothymidine
  • HY-154470
    8-Aza-2’-deoxyguanosine
    		99.93%
    8-Aza-2’-deoxyguanosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    8-Aza-2’-deoxyguanosine
  • HY-138578
    2'-O-Me-C(Bz) Phosphoramidite
    		99.05%
    2'-O-Me-C(Bz) Phosphoramidite is a modified phosphoramidite monomer, which can be used for the oligonucleotide synthesis.
    2'-O-Me-C(Bz) Phosphoramidite
  • HY-106934
    Peldesine
    		Inhibitor
    Peldesine (BCX 34) is a potent, competitive, reversible and orally active purine nucleoside phosphorylase (PNP) inhibitor with IC50s of 36 nM, 5 nM, and 32 nM for human, rat, and mouse red blood cell (RBC) PNP, respectively. Peldesine is also a T-cell proliferation inhibitor with an IC50 of 800 nM. Peldesine has the potential for cutaneous T-cell lymphoma, psoriasis and HIV infection research.
    Peldesine
  • HY-23171
    1,2-Di-O-acetyl-5-O-benzoyl-3-deoxy-3-fluoro-D-ribofuranose
    1,2-Di-O-acetyl-5-O-benzoyl-3-deoxy-3-fluoro-D-ribofuranose is a ribofuranose nucleoside analogue.
    1,2-Di-O-acetyl-5-O-benzoyl-3-deoxy-3-fluoro-D-ribofuranose
  • HY-138602
    5'-O-DMT-N4-Ac-2'-F-dC
    		99.11%
    5'-O-DMT-N4-Ac-2'-F-dC is a modified nucleoside and can be used to synthesize DNA or RNA.
    5'-O-DMT-N4-Ac-2'-F-dC
  • HY-154534
    Alpha-Adenosine
    		99.91%
    Alpha-Adenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    Alpha-Adenosine
  • HY-111627
    5-Aza-7-deazaguanine
    		99.86%
    5-Aza-7-deazaguanine is a substrate for wild-type (WT) E. coli purine nucleoside phosphorylase and its Ser90Ala mutant in the synthesis of base-modified nucleosides.
    5-Aza-7-deazaguanine
  • HY-W048500
    2-Thiothymidine
    		99.75%
    2-Thiothymidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2-Thiothymidine
  • HY-W100234
    5-Methyl-2′-O-methyl-uridine
    5-Methyl-2′-O-methyl-uridine (2'-O-methyl-5-methyluridine) is a thymidine analog. Analogs of this series have insertional activity towards replicated DNA. They can be used to label cells and track DNA synthesis.
    5-Methyl-2′-O-methyl-uridine
  • HY-W402064
    N-Acetyladenosine
    		99.86%
    N-Acetyladenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277).
    N-Acetyladenosine
  • HY-W040329S1
    2'-Deoxyadenosine-13C10
    		≥99.0%
    2'-Deoxyadenosine-13C10 is 13C-labeled 2'-Deoxyadenosine (HY-W040329). 2′-Deoxyadenosine is an adenine nucleoside that inhibits glucose-stimulated insulin release. 2′-Deoxyadenosine inhibits glucose-stimulated increases seen in islet cyclic AMP (cAMP) accumulation. 2'-Deoxyadenosine activates caspase-3 and promotes apoptosis. 2'-Deoxyadenosine inhibits the activity of S-adenosyl-L-homocysteine hydrolase (SAHH). 2'-Deoxyadenosine inhibits the growth of various cells. 2'-Deoxyadenosine has an anticancer effect on colon cancer.
    2'-Deoxyadenosine-<sup>13</sup>C<sub>10</sub>
  • HY-W714356
    N-6-Methyl-2-deoxyadenosine-d3
    		99.94%
    N-6-Methyl-2-deoxyadenosine-d3 is the deuterium labeled N-6-Methyl-2-deoxyadenosine (HY-W011725). N-6-Methyl-2-deoxyadenosine is an adenine nucleoside analogue.
    N-6-Methyl-2-deoxyadenosine-d<sub>3</sub>
  • HY-111642
    3'-Azido-3'-deoxy-beta-L-uridine
    		98.77%
    3'-Azido-3'-deoxy-beta-L-uridine (Compound 25) is a nucleoside derivative. 3'-Azido-3'-deoxy-beta-L-uridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    3'-Azido-3'-deoxy-beta-L-uridine
  • HY-138577
    2'-F-Bz-dC Phosphoramidite
    		99.88%
    2'-F-Bz-dC Phosphoramidite can be used in the synthesis of oligoribonucleotide (such as DNA and RNA). 2'-F-Bz-dC Phosphoramidite also used for synthesis antiviral agent to inhibit the replication of virus. 2'-F-Bz-dC Phosphoramidite contains a phosphorothioate backbone, to synthesise antisense oligonucleotide analogs to induce apoptosis in cancer cells.
    2'-F-Bz-dC Phosphoramidite
  • HY-154157
    2’-O-Methyladenosine 5’-monophosphate triethyl ammonium
    		99.35%
    2’-O-Methyladenosine 5’-monophosphate triethyl ammonium is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277).
    2’-O-Methyladenosine 5’-monophosphate triethyl ammonium