2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Related Products

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Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.

Nucleoside Antimetabolite/Analog Related Products (1908):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-13040
    N-Benzoyl-5'-O-dmtr-2'-O-(2-methoxyethyl)-adenosine
    		99.85%
    N-Benzoyl-5'-O-dmtr-2'-O-(2-methoxyethyl)-adenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277).
    N-Benzoyl-5'-O-dmtr-2'-O-(2-methoxyethyl)-adenosine
  • HY-154524
    1-(2-Deoxy-β-D-threo-pentofuranosyl)thymine
    		99.68%
    1-(2-Deoxy-β-D-threo-pentofuranosyl)thymine is a thymidine analog. Analogs of this series have insertional activity towards replicated DNA. They can be used to label cells and track DNA synthesis.
    1-(2-Deoxy-β-D-threo-pentofuranosyl)thymine
  • HY-W602640
    2'-Deoxyisoguanosine
    		99.81%
    2'-Deoxyisoguanosine is a purine nucleoside analog. 2'-deoxyisoguanosine has low potency and specificity in inhibiting tumor cell growth, similar to other telomerase inhibitors.
    2'-Deoxyisoguanosine
  • HY-45492
    DMT-2'Fluoro-DG(IB) Amidite
    		99.45%
    DMT-2'Fluoro-DG(IB) Amidite (2'-F-ibu-dG Phosphoramidite) is a nucleoside. DMT-2'Fluoro-DG(IB) Amidite can be used to prepare 4'-modified 2'-deoxy-2'-fluorouridine.
    DMT-2'Fluoro-DG(IB) Amidite
  • HY-113225S2
    Guanosine triphosphate-13C dilithium
    		98.2%
    Guanosine triphosphate-13C (GTP-13C) dilithium is 13C-labeled Guanosine triphosphate (HY-113225). Guanosine triphosphate is a native nucleotide. The derivatives of GTP may be used as specific inhibitors against COVID-19.
    Guanosine triphosphate-<sup>13</sup>C dilithium
  • HY-152702
    2,8-Dimethyladenosine
    		98.68%
    2,8-Dimethyladenosine is an adenosine analogue. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. The popular products in this series are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277).
    2,8-Dimethyladenosine
  • HY-I0100
    Methyl 2-deoxy-3,5-di-O-toluoyl-D-ribofuranoside
    Methyl 2-deoxy-3,5-di-O-toluoyl-D-ribofuranoside is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    Methyl 2-deoxy-3,5-di-O-toluoyl-D-ribofuranoside
  • HY-154241
    8-Methyl-2’-deoxyadenosine
    8-Methyl-2’-deoxyadenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    8-Methyl-2’-deoxyadenosine
  • HY-152378
    2’-Deoxy-2’-fluoro-β-D-arabino-6-azauridine
    2’-Deoxy-2’-fluoro-β-D-arabino-6-azauridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2’-Deoxy-2’-fluoro-β-D-arabino-6-azauridine
  • HY-W578275
    3′-O-Methylcytidine
    		98.0%
    3′-O-Methylcytidine is a cytidine analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities.
    3′-O-Methylcytidine
  • HY-111531
    DMTr-LNA-5MeU-3-CED-phosphoramidite
    		98.75%
    DMTr-LNA-5MeU-3-CED-phosphoramidite is a nucleoside derivative.
    DMTr-LNA-5MeU-3-CED-phosphoramidite
  • HY-138130
    L-Guanosine
    		98.0%
    L-Guanosine is the L-configuration of Guanosine (HY-N0097). L-Guanosine is a purine nucleoside with anti-herpesvirus activity. L-Guanosine can be used to prepare supramolecular hydrogel.
    L-Guanosine
  • HY-138601
    5'-O-DMT-N4-Bz-5-Me-dC
    5'-O-DMT-N4-Bz-5-Me-dC is a modified nucleoside. 5'-O-DMT-2'-O-TBDMS-rI can be used in the synthesis of deoxyribonucleic acid or nucleic acid.
    5'-O-DMT-N4-Bz-5-Me-dC
  • HY-152732
    6-Methyluridine
    		99.02%
    6-Methyluridine is a uridine analogue. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents.
    6-Methyluridine
  • HY-132815
    Fostroxacitabine bralpamide
    Fostroxacitabine bralpamide (MIV-818) is an orally active Troxacitabine-based nucleotide proagent. Fostroxacitabine bralpamide has anticancer effects.
    Fostroxacitabine bralpamide
  • HY-138582
    N6-Methyl-dA phosphoramidite
    		99.83%
    N6-Methyl-dA phosphoramidite can be used in the synthesis of oligodeoxyribonucleotides.
    N6-Methyl-dA phosphoramidite
  • HY-W394432
    9-(2-Deoxy-beta-D-ribofuranosyl)-6-methylpurine
    (2R,3S,5R)-2-(hydroxymethyl)-5-(6-methyl-9H-purin-9-yl)tetrahydrofuran-3-ol (9-(2-Deoxy-beta-D-ribofuranosyl)-6-methylpurine) is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    9-(2-Deoxy-beta-D-ribofuranosyl)-6-methylpurine
  • HY-125818S6
    Cytidine-5'-triphosphate-15N3 dilithium
    Cytidine-5'-triphosphate-15N3 (Cytidine triphosphate-15N3 dilithium; 5'-CTP-15N3) dilithium is 15N labeled Cytidine-5'-triphosphate (HY-125818). Cytidine 5′-triphosphate (Cytidine triphosphate; 5'-CTP) is a nucleoside triphosphate and serves as a building block for nucleotides and nucleic acids, lipid biosynthesis. Cytidine triphosphate synthase can catalyze the formation of cytidine 5′-triphosphate from uridine 5′-triphosphate (UTP). Cytidine 5′-triphosphate is an essential biomolecule in the de novo pyrimidine biosynthetic pathway in T. gondii.
    Cytidine-5'-triphosphate-<sup>15</sup>N<sub>3</sub> dilithium
  • HY-152752
    2’,3’-Dideoxy-3’-fluorocytidine
    2’,3’-Dideoxy-3’-fluorocytidine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2’,3’-Dideoxy-3’-fluorocytidine
  • HY-138599
    5'-O-TBDMS-dA
    		99.89%
    5'-O-TBDMS-dA is a modified nucleoside and can be used to synthesize DNA or RNA.
    5'-O-TBDMS-dA